Smarca4 smarca2 synthetic lethality
WebNormal Function. The SMARCA4 gene provides instructions for making a protein called BRG1, which forms one piece (subunit) of several different protein groupings called … WebApr 11, 2024 · Title: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor Presenter: Koichi Ito Session Category: Experimental and...
Smarca4 smarca2 synthetic lethality
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Web2 days ago · Targeting the "synthetic lethal" partner proteins SMARCA2/4 (human chromatin SWI/SNF- Related, Matrix-Associated, actin-dependent regulatory factor subfamily A member 2 and 4), SCR-9140 selectively degrades SMARCA2 to precisely kill SMARCA4-deficient tumors in preclinical studies while preventing damage to normal cells, thus exhibiting … WebFeb 1, 2024 · SMARCA4 is the ATP-dependent catalytic unit of the complex. SMARCA4, as one of the most important mutually exclusive catalytic ATPase subunits, provides energy …
WebSep 2, 2013 · This study proposes a synthetic-lethality therapy for treating cancers deficient in the SWI/SNF catalytic (ATPase) subunit, BRG1/SMARCA4. The strategy relies upon … WebOct 18, 2024 · About SMARCA2 SMARCA2 (BRM) and SMARCA4 (BRG1) are involved in multiple oncogenic processes, including the process that allows DNA to be transcribed to RNA. SMARCA4 mutations enable cells...
WebJun 17, 2024 · Indeed, SMARCA2 knockdown in both SMARCA4-null HCC cell lines, PLC/PRF/5 and SK-Hep-1, exhibited synthetic lethality of HCC cells, whereas highly expressing SMARCA4 Hep3B and Huh7 cells... WebFeb 8, 2024 · However, with BRM014 and ACBI1, we also observed further changes, probably because these compounds in addition to SMARCA4 also target SMARCA2. SMARCA2, which is the less expressed and...
Web2 days ago · Targeting the "synthetic lethal" partner proteins SMARCA2/4 (human chromatin SWI/SNF- Related, Matrix-Associated, actin-dependent regulatory factor subfamily A member 2 and 4), SCR-9140...
WebFeb 24, 2024 · of SMARCA4 and SMARCA2 based on protein degradation could provide promising therapeutic opportunities (WO2016138114; Genentech and Constellation). … great summer vacation at the beachWebDec 1, 2024 · SMARCA2 and SMARCA4-directed synthetic lethal strategies. Aside from synthetic lethal targeting strategies in the context of ARID1A mutations, the SWI/SNF … florian dietrich linked ingreat summer sides dishes for bbqWebJan 19, 2024 · The development of SMARCA4 and SMARCA2 inhibitors would be promising as a synthetic lethal therapy strategy for SMARCA2-deficient cancers and SMARCA4 … great summer vacation dealsWebJun 15, 2024 · SMARCA2 (BRM) and SMARCA4 (BRG1) are the core catalytic subunits of the SWI/SNF complexes, containing an ATPase domain and a DNA binding bromodomain. SMARCA4 protein expression is lost in … florian dietrich oneraWebFeb 22, 2024 · The development of SMARCA4 and SMARCA2 inhibitors would be promising as a synthetic lethal therapy strategy for SMARCA2‐deficient cancers and … florian diedrich storkowWebJul 1, 2024 · Therefore, targeting SMARCA2 in SMARCA4-deleted cancers through the use of selective SMARCA2 degraders induces synthetic lethality. We designed and … florian dewitz