WebNext, the poly-Ig-receptor will be cut after which the extracellular domain of the receptor bound to the IgA molecule, will be released into the lumen of the gastrointestinal or … Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M (pIg) and immune complexes. pIgRs are … See more pIgR is produced among others by intestinal epithelial cells (IECs) and bronchial epithelial cells. pIgR belongs to the family of type I transmembrane proteins. The extracellular portion of the protein contains 6 … See more Polymeric immunoglobulin receptor is responsible for transcytosis of soluble dimeric IgA, pentameric IgM, and immune complexes from … See more • Kaetzel CS (August 2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces". Immunological Reviews. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543. S2CID 43588042 See more Per Brandtzaeg showed that secretory component acts as a plasma membrane receptor on epithelial cells for polymeric immunoglobulin A … See more Cytokinetic Regulation The expression of pIgR is critically regulated by the pro-inflammatory cytokines, such as IL-1, IL-4, TNF-α, and IFN-γ. The transcriptional regulation by different cytokines proceeds through similar pathways, … See more • Polymeric+Immunoglobulin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … See more
Human Gene PIGR (ENST00000356495.5) from GENCODE V39
WebThis CD22-targeted polymer carrier may be useful for siRNA delivery to lymphoma cells. PMID: ... The B-cell receptor IgM was found to be a major in situ trans ligand of CD22. PMID: ... (sialic acid binding Ig-like lectin) family: Tissue Specificity: B-lymphocytes. Database Links: HGNC: 1643. OMIM: 107266. KEGG: hsa:933. STRING: 9606 ... WebDec 1, 2024 · In general, the cell membrane permeability of drugs is a serious problem in drug discovery and development. I have introduced several methods for transmembrane drug delivery [3,4,5,6,7,8,9,10], particularly for drug delivery into cancer cells across the membrane via RME using mAbs, cell-penetrating peptides (CPPs), and tumor-homing … iom pathways
84-2948-85 PIGR, CT (Polymeric Immunoglobulin Receptor, Poly-Ig …
WebThis receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During … WebThis polymer-technology based dye has an excitation maximum (Ex Max) of 407-nm and an emission maximum (Em Max) at 423-nm. Driven by BD innovation, BV421 is designed to be excited by the violet laser (405-nm) and detected using an optical filter centered near 420-nm (e.g., a 431/28-nm or 450/50-nm bandpass filter). WebMetod och analysprincip. Nefelometri, Atellica NEPH 630. Indikation/tolkning. Vid beställning av fria-lätta-Ig-kedjor i serum analyseras S-Kappakedja, fri och S-Lambda-kedja fri och en kvot dem emellan beräknas; P-Kappa/Lambda, fri. En abnormal kvot används som en surrogatmarkör för monoklonal utsöndring av fria-lätta-immunglobulin-kedjor. ontario california planning department