WebFeb 3, 2024 · Neuroscience Autoimmune Diseases of the Nervous System Interferon-beta What we know so far about Myxovirus Resistance Protein A (MxA) as a Biomarker of Interferon-Beta Therapy in Pa- tients... WebFeb 1, 2005 · Skin biopsies from 21 patients suffering from different types of active cutaneous LE were analysed for the expression of MxA, a protein specifically induced by type I interferons, the IFN-inducible protein IP10/CXCL10, and the chemokine receptor CXCR3, characteristic for Th1 cells, by immunohistochemistry.
Frontiers Polymorphisms of the MxA and MxB genes are …
WebDec 1, 2024 · Type I interferons have a crucial role in the progression to established autoimmune diseases. The cellular source and regulation in disease initiation of these cytokines is not clear, but... WebApr 9, 2024 · Respiratory diseases caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV) are frequent causes of the hospitalization of children; nonetheless, RSV is responsible for the most severe and life-threatening illnesses. Viral infection triggers an inflammatory response, activating interferon (IFN)-mediated responses, including IFN … hand clawing nerve
Rare variant MX1 alleles increase human susceptibility to zoonotic …
WebFeb 15, 2016 · Myxovirus resistance protein A (MxA) is a molecule induced after interferon-β injection. The aim of this study was to investigate whether MxA determination one year … WebMX1 codes for myxovirus resistance protein A (MxA), an interferon-induced antiviral guanosine triphosphatase known to control IAV infections in transgenic mice. Most of the MxA variants identified lost the ability to inhibit avian IAVs, including H7N9, in transfected human cell lines. Nearly all of the inactive MxA variants exerted a dominant ... WebMar 15, 2024 · Previously we identified whole blood levels of intracellular myxovirus resistance protein 1 (MxA), measured by an enzyme immunoassay, as a clinically relevant biomarker for type I IFN activity in patients with SS [ 2 ]. Here we assessed the applicability of this assay to detect systemic type I IFN activation in patients with SLE and SSc. hand claw position