Mitotic catastrophe of tumor cells

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August undefined, 2024

Web11 mrt. 2024 · We have identified the mitotic catastrophe (MC) process after MAL-PDT in HeLa human carcinoma cells. The fluorescence microscopy revealed that PpIX was … Web9 jul. 2024 · APAL knockdown causes mitotic catastrophe and massive apoptosis in human breast, lung, and pancreatic cancer cells. Overexpressing APAL accelerates …

Mitotic Catastrophe SpringerLink

WebMitotic Catastrophe MC occurs after failed mitosis. Cells are characterized by an increased frequency of multiple nuclei and micronuclei. MC acts as an oncosuppresive mechanism for the avoidance of genomic instability ( Vitale et al., 2011 ). Web31 mrt. 2024 · Mitotic catastrophe (MC) is a cell death modality induced by DNA damage that involves the activation of cell cycle checkpoints such as the “DNA structure checkpoint” and “spindle assembly checkpoint” (SAC) leading to aberrant mitosis. Depending on the signal, MC can drive the cell to death or to senescence. The suppression of MC favors … dime bank locations long island

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Web29 jan. 2024 · In this study, we investigated in vitro the impact of mitotic arrest on the ability of breast tumor cells to form clusters. By using live imaging and quantitative image analysis, we found that MCF-7 cancer cell aggregation is compromised upon incubation with paclitaxel or vinorelbine, two chemotherapeutic drugs that target microtubules. Web1 jan. 2024 · Mitotic catastrophe is a process of cell death induced by radiation, chemotherapeutic drugs, or hyperthermia. Mitotic catastrophe results from aberrant mitosis, which is followed either by cell death through apoptosis or necrosis or by partial or complete fragmentation of interphase nuclei with eventual cell death or senescence. Web6 okt. 2006 · Our data indicated that genistein inhibits the growth of tumor cells both in vitro and in allograft nude mice by inducing G2 arrest, polyploid cell formation, mitotic catastrophe, and... fort hood dui

Frontiers Molecular Mechanisms of Radiation-Induced Cancer Cell …

Clonogenic Assays to Detect Cell Fate in Mitotic Catastrophe

Web13 feb. 2024 · Because cells in mitotic catastrophe are almost always incapable of further replication, mitotic catastrophe is often confused as a bona fide cell death type. However, these cells eventually trigger one of the ‘other’ cell death pathways, or less commonly escape from this state (Gascoigne and Taylor, 2008; Vakifahmetoglu et al., 2008 ... WebMitotic catastrophe is induced by different classes of cytotoxic agents, but the pathways of abnormal mitosis differ depending on the nature of the inducer and the status of cell … dime bank patchogue nyWeb10 apr. 2024 · HIGHLIGHTS who: Tsung-Ming Chen and collaborators from the Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, New Taipei City, Taiwan have published the article: KDM5D Histone … Kdm5d histone demethylase identifies platinum-tolerant head and neck cancer cells vulnerable to … dime bank routing number new york

"Web12 sep. 2024 · As a broad definition, it is currently accepted that mitotic catastrophe is cell death occurring during mitosis ensuing from DNA damage or other aberrations affecting the mitotic process, such as malfunctions in the mitotic machinery. " - Mitotic catastrophe of tumor cells

Mitotic catastrophe of tumor cells

Docetaxel induces cell death through mitotic catastrophe in …

Web18 okt. 2024 · There is evidence that MB and glioma cells share molecular profiles with progenitors of cerebellar granules and of cortical radial glia cells, in which MCPH gene … WebMorphological markers of mitotic catastrophe in Wip1-expressing premature senescent tumor cells. A, shown is microscopic analysis of senescent AGFP, AWIP1, MGFP and …

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WebMitotic catastrophe represents a step preceding apoptosis or necrosis, depending on the expression and/or proper function of several proteins. Mitotic catastrophe was proposed … Web9 sep. 2024 · Cells surviving this mitotic catastrophe result in therapy-resistant cancer stem-like PGCCs (15,17,18). DNA damage repair pathways may be essential for PGCCs to survive mitotic catastrophe . To determine if mTORi could be impacting mitotic spindles, we stained tumor cells with α-tubulin to evaluate mitotic spindle organization.

WebWhile the term mitotic catastrophe has been used to describe a type of cell death that occurs during mitosis, there is still no broadly accepted definition. Occasionally, mitotic … Web1 feb. 2016 · An analysis of mitotic catastrophe induced cell responses in melanoma cells exposed to flubendazole. K. Rudolf, E. Rudolf Biology Toxicology in vitro : an international journal published in association with BIBRA 2024 6 Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells Deokbae Park, Jung-Hee Lee, S. Yoon

Web24 feb. 2024 · Our results indicate that SMC1A acetylation at K579 results in mitotic catastrophe and inhibits tumor cell growth by regulating its phosphorylation. To further address the role of SIRT2-SMC1A axis in tumorigenesis, we asked whether an association between SIRT2 and SMC1A is present in colon cancer. Web19 mei 2016 · Microtubule poisons inhibit spindle function, leading to activation of spindle assembly checkpoint (SAC) and mitotic arrest. Cell death occurring in prolonged mitosis is the first target of microtubule poisons in cancer therapies. However, even in the presence of microtubule poisons, SAC and mitotic arrest are not permanent, and the surviving cells …

Web5 jul. 2011 · Mitotic catastrophe as anticancer strategy Cancer cells often have a deficient G 1 -checkpoint, for instance because of deficient p53 signaling, which can result in increased DNA damage at the G 2 -checkpoint compared with normal cells ( 21 ). Abrogation of the G 2 -arrest releases cells with unrepaired DNA damage into premature …

Web23 nov. 2024 · Mitotic catastrophe is a cellular response that senses mitotic failure and drives cells to an irreversible antiproliferative fate leading to cell death or senescence 29. As such,... dime bank routing number honesdale paWeb30 okt. 2024 · The action of TTFields in each phase of the cell cycle and the link between TTFields, DNA repair pathways and mitotic catastrophe remain to be characterized. One promising area of investigation could evaluate whether TTFields exert their function selectively on tumor cells by affecting microtubule biology through centrosomes. fort hood education center emailWeb9 jul. 2024 · Effects of Aurora A/PLK1–associated long noncoding RNAs (APAL) knockdown in mitotic catastrophe. A–B) The effect of APAL knockdown on mitosis. T47D cells transfected with locked nucleic acids (LNAs) were immunostained with α-tubulin and γ-tubulin. The percentages of abnormal mitotic cells were calculated in B. Scale bar = 10 … fort hood early payWeb14 okt. 2005 · Mitotic catastrophe is characterized by the occurrence of aberrant mitosis, or missegregation of the chromosomes, followed by cell division. Nuclear envelopes form around individual chromosomes or groups of chromosomes forming large nonviable cells with multiple micronuclei, which are morphologically distinguishable from apoptotic cells. dime bank routing number hawley paWeb10 okt. 2005 · However, mitotic catastrophe is considered to be one of the most important death modalities after ionizing radiation, and some of its mechanistic aspects have been revealed very recently: In... dime bank taftville connecticutWebPP2A, a serine/threonine phosphatase composed of 3 distinct subunits—65-kDa PP2A-A (scaffold subunit), 55-kDa PP2A-B (regulatory subunit), and 37-kDa PP2A-C (catalytic subunit)—constitutes 0.2%–1.0% of the total protein content in mammalian cells and has been implicated in the regulation of diverse cellular processes, including signal … fort hood ed center phone numberWeb13 jan. 2005 · Mitotic catastrophe is a term used to describe the failure of mitosis. In budding yeast, it is caused by chromosome missegregation and followed by cell death (10, 11). DNA damage induces mitotic catastrophe in mammalian cells that results in the formation of cells with either multimicronuclei or two nuclei (12–14). dime bank taftville ct hours