WebSep 14, 2024 · There is increasing evidence that lysosomal acidification affects the activity of various hydrolases within the lysosome, as well as various additional signal functions of the lysosome, especially the regulation of nutrient sensing and nutrient homeostasis [26,54]. The proper coordinated function of multiple ion channels is involved in the ... WebAug 29, 2024 · Acidification inhibitors do not cause parasite death. Amebae pretreated with ammonium chloride for 1 h were incubated for 5, 20, or 40 min in medium containing ammonium chloride. ... We show that interference with lysosomal acidification impairs amebic trogocytosis, phagocytosis, and cell killing, indicating that amebic lysosomes are …
Beyond Indigestion: Emerging Roles for Lysosome-Based …
WebThe dominant effect of the lysosomal acidification inhibitor Baf agrees with the increased membrane trafficking and lysosomal acidification elicited by Wnt treatment of GSK3 … WebMay 3, 2024 · A V-ATPase inhibitor from this class, namely omeprazole, is used to treat peptic ulcers and cancer. NiK12192 is a small molecule indole derivative that causes a reduction in the volume and... south london and maudsley logo
Frontiers The mechanism of NLRP3 inflammasome activation …
WebFeb 2, 2024 · Lysosome acidification is achieved by vacuolar ATPase (V-ATPase), which allows protons to enter the lysosome lumen in an ATP-dependent manner (Ohkuma et al, 1982; Breton & Brown, 2013 ). However, the mechanism by which ATP is supplied to V-ATPase in lysosomes is not well understood. WebDec 1, 2012 · Moreover, inhibition of MTOR by PP242, an inhibitor of MTOR complex1/2, abrogated the changes in both LC3-II and SQSTM1 in AURKA-overexpressing BT-549 cells, suggesting that AURKA-suppressed autophagy might be associated with MTOR activation. WebSep 2, 2024 · Regulating the function of v-ATPase may impact lysosomal activity and, hence, the acidification of specialized cells and diverse signalling pathways, such as … south london and maudsley mental health