Genetically predicted
WebApr 12, 2024 · Here, we propose AI-DTI, a novel method that predicts activatory and inhibitory DTIs by combining the mol2vec and genetically perturbed transcriptomes. We … WebNov 27, 2024 · Association of genetically predicted cortisol with IHD, ischemic stroke, T2DM, and other CVD risk factors Genetically predicted cortisol. Single nucleotide polymorphisms (SNPs) strongly (P < 5 × 10 −6) and independently (r 2 < 0.001) associated with morning fasting plasma/serum cortisol were used as genetic instrumental …
Genetically predicted
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WebFeb 25, 2024 · Genetically predicted effects were generally consistent among drug targets, which were intended to modify the same lipoprotein lipid trait. For example, the linear fit for the MR estimates on all 249 metabolic traits for genetically predicted inhibition of LDL cholesterol lowering targets HMGCR and PCSK9 was r 2 = 0.91. WebDec 7, 2024 · Discussion. It remains controversial whether T2DM is a risk factor for COVID-19 severity and susceptibility. Most MR studies failed to show significant effects of …
WebMar 22, 2024 · Results: We found that genetically predicted green tea intake was causally associated with a lower risk of arterial embolism and thrombosis (IVW odds ratio [OR] per SD decrease in green tea intake = 0.92 [95% confidence interval, 0.85-0.99]; p = 0.032). Moreover, the sensitivity analysis (both MR Egger regression and weighted median) … WebJan 5, 2024 · Associations of usual systolic blood pressure (SBP) and genetically-predicted SBP with stroke types, major coronary events and major vascular events. The …
WebFeb 22, 2024 · Genetically predicted higher education level was associated with lower body mass index and fewer cigarettes smoked per day in the univariable model; the … WebJul 28, 2024 · Associations between genetically predicted insomnia and 17 cardiometabolic risk factors. Results were obtained from the multiplicative …
Web12 hours ago · The iconic image of the supermassive black hole at the center of M87 has gotten its first official makeover based on a new machine learning technique called PRIMO. The team used the data achieved ...
Web12 hours ago · Seen from Earth, the giant elliptical galaxy M87 is just a two-dimensional blob, though one that appears perfectly symmetrical and thus a favored target of amateur astronomers. hubungan inflasi dengan pengangguran terbukahubungan inflasi dengan emasWebAug 23, 2016 · Analyses using categorical variables of genetically predicted BMI showed inverse results similar to analyses treating predicted BMI as a continuous variable. We … hubungan inflasi dan ihkWebMar 22, 2024 · Results: We found that genetically predicted green tea intake was causally associated with a lower risk of arterial embolism and thrombosis (IVW odds ratio [OR] … hubungan insulin dan glukosaWebMar 15, 2024 · Furthermore, we also tested whether genetically predicted 25OHD and COPD shared a variant in a specific region using symbiosis analysis with PP.H4 values > 0.75 were considered a mark of symbiosis . In addition, we adopted the MR Steiger approach to estimate the orientation on exposure and outcome of each extracted IV . … hubungan inflasi dengan pertumbuhan ekonomiWebFeb 26, 2024 · Higher genetically predicted SHBG levels were associated with a reduced risk of hypertension, type 2 diabetes, diabetic complications, coronary atherosclerotic outcomes, gout and benign and malignant neoplasm of uterus, but an increased risk of varicose veins and fracture (mainly in females). Higher genetically predicted … hubungan insan dengan alam metafizikWebApr 6, 2024 · Between 1984 and 2010, the 17,988 participants were enrolled in sub-studies of the Swedish Twin Registry. Midlife obesity was associated with a higher risk of CVD across all PGS BMI categories, but the association was stronger with genetically predicted lower BMI (hazard ratio from 1.55 to 2.08 for those with high and low PGS BMI, … hubungan insentif dan kepuasan kerja