Dimethylsphingosine
Webdimethylsphingosine (DMS) induced accumulation of phytoalexin in potato tubers. In potato, tobacco and Nico-tiana benthamiana, DMS also induced rapid cell death. DMS-treated potato cells stained with 40,6-diamidino-2-phenylindole (DAPI) showed chromatin condensation, and isolated DNA from DMS-treated cells had ladder pattern, WebSep 1, 2006 · Objective:N, N -Dimethylsphingosine (DMS) is recognized as an inhibitor of sphingosine kinase (SphK), a key enzyme responsible for the formation of sphingosine-1-phosphate (S1P). We previously showed that S1P was cardioprotective and that SphK was critical for myocardial ischemic preconditioning.
Dimethylsphingosine
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WebOur studies have demonstrated that ethanol exposure in P7 mice (5.0 g/kg, once) induces, within 2–4 h, transient activation of SphK2 and a similar transient increase in S1P in the brain. Because an inhibitor of SphKs, dimethylsphingosine, attenuates ethanol-induced apoptosis, S1P may enhance apoptosis in this system . WebN,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of …
Web最新美国发明专利 / 2024-02-16 WebN,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of sphingosine kinase. DMS levels are elevated in the spinal cord, and contributes to allodynia, in a transected-nerve model of neuropathic pain. 특징 및 장점
WebOct 24, 2014 · Here we provide evidence that DMS is present in human CNS tissue. We show that DMS levels increase in demyelinating lesions isolated from patients with multiple sclerosis, an autoimmune disease in which the majority of patients experience chronic pain. WebPubMed
WebSep 15, 1998 · N,N-Dimethylsphingosine (DMS) inhibits sphingosine kinase and has been used to investigate the biological roles of SPP; however, little is known of the …
WebEndogenous sphingolipid metabolites such as ceramides and sphingosines have been increasingly recognized as lipid mediators of cell growth, differentiation and apoptosis. We have previously studied the ability of sphingosine (Sph) and N,N-dimethylsphingosine (DMS) to induce apoptosis in a variety of solid tumor cell lines. dr christopher manning rheumatologistWebJul 21, 2024 · Chagas disease cardiomyopathy is a parasite-driven inflammatory disease to which there are no effective treatments. Here … dr christopher manning southington ctWebN,N-Dimethylsphingosine (also known as DMS) is an inhibitor of sphingosine kinase. In rats with neuropathic pain, the natural metabolite DMS is unregulated in the dorsal horn. … dr christopher mann nc