WebAug 23, 2024 · Because CTCF binding to genomic DNA is important for the maintenance of genomic integrity and CTCF is an RNA-binding protein (28–31), we performed RNA immunoprecipitation (RIP) analysis, demonstrating that the ZF DNA- and RNA-binding domains of CTCF are important for their binding to not only an exogenous hSATII RNA … WebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source Gene type RefSeq status Organism Lineage Also known as Summary This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains.
CTCF ChIP-seq - emanlee - 博客园
WebApr 10, 2024 · Similar to the genome organization profiles, CTCF-binding patterns reflected lineage proximity of the subsets, with a higher overlap of CTCF peaks for the MP and TE subsets versus naive cells (Figures 2 B and S1 G–S1I). Naive T cell-associated CTCF binding was diminished upon effector cell differentiation (Figures 2 C, S1 H, and S1I). WebLack of CTCF binding allows the boundaries of DNA methylation to spread, and when those boundaries were pushed close to promoters, gene expression was reduced Ultimately, it looks like CTCF may be avoiding 5mC in order to spend time with its oxidized cousins 5hmC and 5fmC, at least in specific genomic contexts. easily accessible 中文
CTCFBSDB 2.0 Test: A database for CTCF binding sites and genome ...
WebWe noticed that multiple CTCF-binding sites are present in the BCL11B enhancer region that are complementary (convergent) to those found in the transcriptional regulatory regions of BCL11B and TLX3 (Figure 4 A). Seventeen out of 31 patients and both cell lines contained CTCF deletions or mutations, whereas 14 patients were CTCF wild type. WebPromoter-proximal CTCF binding is correlated with the transcription of over 2,000 genes across a diverse set of adult tissues. Taken together, the results of our study show that CTCF binding to promoters may promote long-distance enhancer-dependent transcription at specific genes in diverse cell types. WebCTCF. Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5] … easilocks extensions