Cisplatin nmr
WebOct 16, 2013 · To monitor cisplatin-induced cell killing, a cell viability assay using ATPlite 1 Step kit (Perkin Elmer) was performed according to the manufacturer’s instructions followed by luminescence measurement … WebHowever, like cisplatin and transplatin, only the cis isomer has anti-cancer activity, whereas the trans-isomer does not. ... The solution structure of the platinum-DNA adducts has been studied by two-dimensional NMR spectroscopy. Both the cis-platinum adducts and the trans-platinum adducts destabilize the DNA duplex significantly. The melting ...
Cisplatin nmr
Did you know?
WebJan 11, 2024 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is a widely used chemotherapeutic drug in the treatment of various types of cancers, including testicular, bladder, ovarian, breast, head and neck, and small and non-small cell lung cancers. WebApr 9, 1999 · The direct detection of 195 Pt- and 15 N-NMR signals was widely used in early studies of reactions of cis -diamminedichloroplatinum (II) ( cis -DDP) with various biomolecules. The 195 Pt chemical shift is sensitive to the nature of the bound donor atoms as well as to geometrical isomerism and chiral centres.
WebApr 1, 2014 · 1 H and 13 C NMR spectra were recorded on a Bruker AV 400 NMR spectrometer in DMSO-d 6. Fourier transform infrared (FT-IR) spectra were recorded on a Bio-Rad Win-IR instrument using KBr method. ... Moreover, cisplatin crosslinking could largely enhance micellar stability and might effectively prevent premature drug release … WebPt NMR shows that cisplatin is not produced in the reaction medium. Although the Pt(II) products bind to closed circular DNA, their effect on the mobility of Form I DNA is different from that produced by cisplatin. When physiolog-ical carbonate is present in the reduction medium, 13. C NMR shows that Pt(II) carbonato complexes form
WebOct 3, 2013 · In this work, 1H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to characterize the variations in the metabolome (small metabolites and mobile lipids) of A549 human lung cells in response to exposure to the alkylating drug cisplatin. Multivariate analysis and signal integration of …
WebSep 19, 2009 · Cisplatin [ cis -diamminedichloridoplatinum (II)] is used in chemotherapy where platinum–DNA adducts initiate tumor cell death. It is possible that side effects such as neurotoxicity and cellular cisplatin resistance can be due to interaction of cisplatin with lipids and the phospholipid bilayer.
WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … how large is brazil in square milesWebFeb 1, 2012 · Cisplatin, 1, was used as purchased (Sigma-Aldrich, St. Louis, MO). Stock solutions of the platinum compounds in distilled water, 1 and 3, or DPBS (Dulbecco's phosphate buffered saline) buffer, 4, were in the range of 40–650 μM. how large is brave browserWebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high … how large is botswanaWebMay 1, 2024 · The equilibrium structures of cisplatin and transplatin were optimized, and their 1 H, 15 N, and 195 Pt NMR chemical shifts were evaluated at both non-relativistic and fully relativistic four-component levels. Reliable correlations with experimental data were achieved at the DFT level with taking into account relativistic effects in calculations of … how large is cebuWebNov 13, 2024 · H NMR-based metabolomics strategy was carried out, for the first time to our knowledge, to assess the impact of cisplatin on the metabolism of the kidney , adding the novel study of how large is cedar pointWebMay 26, 2024 · Cisplatin is a well-known chemotherapeutic drug for solid tumors and leukemia with muscle toxicity, and long-term cisplatin medication can induce aberrant … how large is capital one bankWebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. … how large is chernarus