WebDec 16, 2016 · DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the … WebHeterochromatin-associated protein 1 (HP1) [1] is thought to affect chromatin structure through interactions with other proteins in heterochromatin [2]. Chromo domains located near the amino (amino chromo) and carboxy (chromo shadow) termini of HP1 may mediate such interactions, as suggested by domain swapping, in vitro binding and 3D …
GENES & DEVELOPMENT September 15, 2007 Contents
WebProteins that possess a chromo domain are well-known for their roles in heterochromatin assembly and maintenance. The Heterochromatin Protein 1 (HP1) family, with a chromo domain and carboxy-terminal chromo shadow domain, targets heterochromatin through interaction with histone H3 methylated on lysine 9 (H3K9me2/3). WebFeb 24, 2024 · The HTML element—an obsolete part of the Web Components technology suite—was intended to be used as a shadow DOM insertion point. You might … first presbyterian church of bristol
Chromo and Chromo Shadow Domains - Modular Protein …
WebDec 15, 2024 · Its chromo shadow domain (CSD) homodimerizes, a requirement for binding protein partners that contain a PXVXL motif. How does HP1a select among its many different PXVXL-containing partners? HP1a binds tightly to Heterochromatin Protein 2 (HP2), but weakly to PIWI. WebDec 3, 2024 · By computational analysis, we found at L1's C-terminal end the chromo shadow domain-binding motif PxVxL, which directs the binding of nuclear proteins to … WebStructures of the Chromo and Chromo Shadow Domains. Function of the Chromo Domain. Genetic, Cytological, and Molecular Properties of the Chromo Domain. Emerging Research Directions and Recent Developments. References. Citing Literature. Modular Protein Domains. Related; Information; Close Figure Viewer. first presbyterian church of burbank