Chk1 s296
WebAntibodies Primary Antibodies Phospho-Chk1 (S296) Rabbit mAb Phospho-Chk1 (S296) Rabbit mAb Cat. No.: HY-P80455 Rabbit Monoclonal Antibody] to Chk1 (phospho S296) … WebNov 21, 2011 · The Cdk1-cyclin A complex regulates late origin firing in S-phase. A constitutively activated Cdk1 allele increases firing of late S-phase origins, whereas a loss of function temperature sensitive allele of Cdk1 has a defect in late origin firing at the restrictive temperature [ 76 ]. 4.2.3. The G2/M transition
Chk1 s296
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WebOct 24, 2016 · A similar analysis of tumour cells growing anchorage-dependently revealed a very weak correlation between Chk1 S296 phosphorylation and Cdc6 (R 2 = 0.219) but a similar correlation between total ... WebRayBio® Human Phospho-CHK1 (Ser296) and Total CHK1 ELISA Kit Catalog #: PEL-CHK1-S296-T User Manual Last revised May 19, 2024 Caution: Extraordinarily useful …
WebFeb 7, 2011 · RayBio® Phospho-CHK1 (Ser296) ELISA kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological … WebJun 10, 2014 · Phosphorylation of Chk1 on either serine 296, 317 or 345 was highly variable across the cell lines investigated. No correlation between Chk1 expression levels or phosphorylation on serine 296, 317 or 345 and sensitivity to …
WebAug 7, 2014 · Inhibition of Chk1 in these sensitive cell lines induced DNA damage and caspase-3/7 dependent apoptosis. Western blot profiling identified pChk1 (S296) as a predictive biomarker of Chk1 inhibitor sensitivity in ovarian and triple-negative breast cancer and pH2AX (S139) in luminal breast cancer. WebAug 7, 2014 · This finding suggests that Chk1 inhibitors either as single agents or in combination chemotherapy represents a viable therapeutic option for the treatment of triple-negative breast cancer. pChk1 (S296) tumor expression levels could serve as a useful biomarker to stratify patients who might benefit from Chk1 inhibitor therapy. Peer Review …
WebJul 9, 2024 · However, CHK1i inhibited S296 autophosphorylation of CHK1 in both cells (Fig. 1f) [ 13, 14 ], suggesting that CHK1 activity remains inhibited by CHK1i; thus drug efflux is unlikely a major...
WebCitations: (65) Cell Signaling Technology's Phospho-Chk1 (Ser296) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. Phospho-Chk1 (Ser296) Antibody detects endogenous levels of Chk1 only when phosphorylated at serine 296. how much 401k loan can i takeWebNational Center for Biotechnology Information how much 4 digit numbers are thereWebCHEK1 (Phospho-S296) antibody CHEK1 (Phospho-S296) antibody Catalog Number: orb570889 Be the first to review this product Datasheet Select Product Size 50 μg 100 … how much 5-htp should i take dailyWebImmunostains of γH2AX and pChk1 (S296) on serial tumor biopsies from four patients demonstrated an induction of DNA damage and Chk1 activation following irinotecan. However, Chk1 inhibition by UCN-01 was not observed in all tumors. Most tumors were basal-like (69 %), and carried mutations in TP53 (53 %). how much 50g golden virginiaWebProduct name Anti-Chk1 (phospho S296) antibody [EPR915] See all Chk1 primary antibodies Description Rabbit monoclonal [EPR915] to Chk1 (phospho S296) Host … how much 500 dollars in philippinesWebPrexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC 50 =8 nM) and RSK1 (IC … how much 500 pounds in us dollarsWebRayBio® Phospho-CHK1 (Ser296) and Total CHK1 ELISA kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological … how much 5 att prepaid plans cost