WebAs a protein kinase which can attenuate activations of Akt and JNK, we focused on Budding uninhibited by benzimidazole-1 (Bub1). Bub1 was first identified as a cell cycle-related … WebFeb 1, 2015 · The screen successfully identified many proteins with known roles, and the authors chose to characterize budding uninhibited by benzimidazole 1 (BUB1) as a target using a high stringency strategy for selection. BUB1 was validated in six malignant and non-malignant human cell lines from various tissues in which siRNA activity abrogated the ...
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WebAug 13, 2024 · In humans, a major player in determining this balance is the PP2A-B56 phosphatase which is recruited to the Kinase Attachment Regulatory Domain (KARD) of the Spindle Assembly Checkpoint protein Budding Uninhibited by Benzimidazole 1-related 1 (BUBR1) in a phospho-dependent manner. WebBudding uninhibited by benzimidazoles 1 (BUB1) is a mitotic checkpoint serine/threonine kinase that has been presented as an oncogene or tumor suppressor gene in many types of cancer, including... michael meiring my life
Bub1 kinase in the regulation of mitosis - tandfonline.com
WebFeb 1, 2024 · MBIC was also reported to inhibit microtubule polymerisation, through the up-regulation of cyclin B1, cyclin-dependent kinase 1 (CDK1), and budding uninhibited by … WebMar 5, 2024 · Budding uninhibited by benzimidazoles 1 (BUB1) is a mitotic checkpoint serine/threonine kinase that has been reported as an oncogene or tumor suppressor gene in various types of cancer, including breast cancer, pancreatic ductal adenocarcinoma, prostate and gastric cancers. However, its role in liver cancer remains unclear. The … WebJul 2, 2024 · Budding uninhibited by benzimidazole 3 (BUB3) is a WD40 repeat protein that is highly conserved among eukaryotic organisms 1.In fungi and animals, BUB3 is an essential component of the spindle ... michael meighen toronto